Scientific Programme  


Preliminary Scientific Programme (Venues to be confirmed)

The programme of PRION 2008 will include all contemporary topics in Prion Disease.

Scientific sessions will be organised covering all the important subjects in the TSE field.

Topics

  • Basic mechanics of neurodegeneration: Healthy and degenerating neurons
  • Diagnostics
  • Emergent strains
  • Epidemiology
  • Genetics
  • In vitro and in vivo replication
  • Prion transmission and pathogenesis
  • Protein misfolding in neurodegenerative disease
  • Risk assessment
  • The functions and cell biology of PrPc
  • Therapeutics
  • Yeast prions
  • IFPA session: Progress with blood safety and prions

Menu

Tuesday 7th October 2008

08:30-09:30. Registrations
Auditorium Hotel
09:30 –15:00. Workshop: “TSEs in goats, cervids and sheep”
Auditorium Hotel(Roma Room)
Chair: Dr. Jan Langeveld
10.00 - 13.00. Public TSE Lecture: “Scrapie en oveja”
INIA (Salon de Actos). Carretera de la Coruña Km 7,5
Chairs: Dr. Juan Maria Torres, Dra. Malena Serrana
16.00 - 19.00. Public TSE Lecture: “Encefalopatias Espongiformes Humanas”


Información adicional:jpedro@isciii.es


Wednesday 8 October 2008

Horario Auditorium Horario Roma room
8:45-9:15 Opening Ceremony  
9:15-9:45 (S1) Plenary conference:
Dr. Charles Weissmann
9:50-11:10 (1) Session 1. Basic mechanism of neurodegeneration
Chair:		 10:00-13:00 (4) Session 4. Epidemiology & risk assessment
Chair:
9:50-10:10 (OC1.1) Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a New Transgenic Mouse Model
 09:50-10:10 (OC4.1) Comparative analysis of the trend of the BSE epidemic across Europe, in relationship with control measures
10:10-10:30 (OC1.2) Identification of Neuron-specific gene Regulatory Circuits Involved in Prion-Induced Neurodegeneration
 10:10-10:30 (OC4.2) Increasing the age limit in active BSE surveillance to 48 months: How many cases will we miss?
10:30-10:50 (OC1.3) Cyclin dependent kinase 5 phosphorylation induces prion protein conformational change.
 10:30-10:50 (OC4.3) Scrapie control through selective breeding in the Netherlands: when will it be achieved?
10:50-11:20 Coffee break
11:20-13:00 (2) Sesion 2. protein misfolding
Chair:		 11:20-13:00 (4) Session 4. Epidemiology & risk assessment (cont.)
Chair:
11:20-11:40 (OC2.1) X-ray fiber diffraction reveals major structural differences between brain-derived prions and recombinant prion protein amyloid
 11:20-11:40 (OC4.4) A case control study on atypical scrapie in French sheep
11:40-12:00 (OC2.2) Limited proteolysis of PK-sensitive PrPSc further supports a structure featuring beta sheet stretches interspersed with loops/turns for PrPSc
 11:40-12:00 (OC4.5) Diagnostic profile of young patients referred to the CJD Italian surveillance unit
12:00-12:20 (OC2.3) Different strains have different “most infectious” particles
 12:00-12:20 (OC4.6) Human transmissible Spongiform Encefalopaties in Spain, 1993-2008.
12:20-12:40 (OC2.4) In vivo transmission of Alzheimer’s disease by a prion like mechanism.
 12:20-12:40 (OC4.7) Combining Quantitative Models for BSE and vCJD: Developing an Accessible Tool for Prion Disease Risk Analysis
12:40-13:00 (OC2.5) Infectious and non-infectious aggregates of the prion protein share several conformational epitopes
 12:40-13:00 (OC4.8) TSE Roadmap – Results of a comparative study of risk perception and risk communication of stakeholders within European countries
13:00-14:20 Lunch / Poster Session
14:20-15:00 (S2) Plenary conference:
Dr. Reed Wickner		  
15:00-17:00 (3) Session 3. Prion transmission & pathogenesis
Chair:		 15:00-16:20 (5) Session 5.The function & cell biology of PrP (4)
Chair:
15:00-15:15 (OC3.1) Transmission of atypical BSE to Microcebus murinus, a non-human primate: Development of clinical symptoms and tissue distribution of PrPres.
 15:00-15:20 (OC5.1) Association of cellular prion protein and sphingolipid-mediated signaling pathways
15:15-15:30 (OC3.2) Oral transmission of BSE in resistant ARR/ARR sheep: involvement of lymphoid tissues
15:20-15:40 (OC5.2) Dose independent modulations of glutamate receptors expression and neuronal excitability by PrPc in vivo.
15:30-15:45 (OC3.3) Prions hi-jack tunneling nanotubes for intercellular spread
 15:40-16:00 (OC5.3) Signalling and endocytosis: coupled mechanisms in cellular prion physiological functions
15:45-16:00 (OC3.4) New hospital prion decontamination procedures using copper-hydrogen peroxide formulations with optimal chemical compatibility and reduced safety risks
 16:00-16:20 (OC5.4) Effect of disease-associated mutations in the prion protein on the beta-secretase cleavage of the amyloid precursor protein
16:00-16:15 (OC3.5) Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay
 16:20-17:00 (6) Session 6 - Genetics
Chair:
16:15-16:30 (OC3.6) Neuroinvasion in sheep TSEs: the role of the haematogenous route
 16:20-16:40 (OC6.1) Transcriptional Regulation of Prion Protein Gene Expression by SP1 and MTF1
16:30-16:45 (OC3.7) The Structure of Rabbit PrP-C: Clues into TSE fibril formation and the species barrier.
 16:40-17:00 (OC6.2) Cathepsin D C224T polymorphism in sporadic and genetic Creutzfeldt-Jakob disease
16:45-17:00 (OC3.8) Prions in milk from ewes incubating natural scrapie
 17:00-17:20 (OC6.3) Investigation of protein-protein interactions from scrapie infected mice brain tissue using NAPPA
17:00-17:15 (OC3.9) TSE neuroinvasion is dramatically impaired in aged mice
  
17:20-20:00 Welcome Reception/Poster Party

Thursday 9 October 2008

Horario Auditorium Horario Roma room
9:00-09:30 (S3) Plenary conference
Dr. Susan Lindquist		  
9:30-13:00 (3) Session 3. Prion transmission & Pathogenesis (cont.) 9:30-13:00 (9) Session 9. Diagnostics
9:50-10:10 (OC3.10) Reversible changes of PrPSc after transmission in animals with mismatched prion proteins
 09:30-09:50 (OC9.1) BSE / Scrapie intracerebrally co-infected sheep: Scrapie hides BSE in the brain, not in lymphoid tissues
09:45-10:00 (OC3.11) Strain targeting without strain-specific axonal transport or neuronal tropism
 09:50-10:10 (OC9.2) Sensitive Biomarker Detection of Protein Folding Disorders; Proximity Ligation-based detection of protein Oligomers
10:00-10:15 (OC3.12) vCJD in primate: new insights for blood risk assessment
 10:10-10:30 (OC9.3) The Identification of Biomarkers in the Urine of BSE Infected Cattle
10:15-10:30 (OC3.13) The Sup35p NM domain propagates as a prion in mammalian cells
 10:30-10:45 (OC9.4) Protein misfolding cyclic amplification combined with the conformation dependent immunoassay as a potential confirmatory blood test for variant Creutzfeldt-Jakob Disease
10:30-10:45 (OC3.14) The influence of PrP glycosylation for the spreading of the TSE infectious agent and in determining the strain characteristics.
 10:45-11:00 (OC9.5) High resolution quantification and differentiation of PrPSc forms in mixed BSE and scrapie samples by N-TAAP demonstrates potential for detection of co-infection.
10:45-11:00 (OC3.15) The glycosylation of prion protein is not required for the prion strain formation
 		11:00-11:10 (OC9.6) Specificity and capacity of the P-Capt® filter for prion protein and prion infectivity
11:10-11:40 Coffee break
11:40-13:00 (7) Session 7. Emergent strains
Chair:		 11:40-13:00 IPFA Session:
Progress With Blood Safety and Prions
11:40-12:00 (OC7.1) BASE in sheep displays strain features distinct from BSE and scrapie
 11:40-12:05 Do sporadic or genetic CJD pose a risk through blood or blood products?
12:00-12:20 (OC7.2) When Atypical Scrapie cross species barriers.
 12:05-12:20 Update on blood screening tests (yet again), with some ‘strategic’ comments
12:20-12:40 (OC7.3) Mutational changes affecting thermostability of TSE agent-strains?
 12:20-12:35 Blood based assays for infection with the agent of vCJD.
12:40-13:00 (OC7.4) North American Cervids Harbor Two Distinct CWD Strains
 12:35-13:00 Spiking for blood product validation
13:00-14:20 Lunch / Poster Session
14:30-15:00 (S4) Plenary conference: Dr. Baron  
15:00-18:00 (8) Session 8. In vitro and in vivo replicatio
Chair:		 15:00-18:00 (10) Session 10. Therapeutics
Chair:
15:00-15:20 (OC8.1) In vitro amplification of PrPSc derived from brain and blood of sheep infected with scrapie
 15:00-15:20 (OC10.1) An Update on the First U.S. Treatment Trial for Sporadic Jakob-Creutzfeldt Disease (sCJD)
15:20-15:40 (OC8.2) Generation of a constellation of new prions in vitro leading to the emergence of novel prion diseases.
 15:20-15:40 (OC10.2) Single localized treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease.
15:40-16:00 (OC8.3) Persistent propagation of mouse-adapted vCJD and Fukuoka-1 agents in murine stromal cell cultures of bone marrow and spleen origin.
15:40-16:00 (OC10.3) Therapeutic benefit from gene therapy in the curative treatment of prion diseases
16:00-16:15 (OC8.4) THE SAME PRIMARY STRUCTURE OF THE PRION PROTEIN YIELDS TWO DISTINCT SELF-PROPAGATING STATES
 16:00-16:20 (OC10.4) Antibodies directed against the prion protein receptor LRP/LR provide alternative tools in prion diseases
16:15-16:30 (OC8.5) In vitro studies of the transmission barrier
 16:20-16:40 (OC10.5) Italian trial with doxycycline in Creutzfeldt-Jakob disease: background, study protocol and update on study population
16:30-16:45 (OC8.6) Scrapie production occurs in the the perinuclear recycling compartment
16:40-17:00 (OC10.6) High Throughput Screening to Identify Therapeutics for Human Prion Disease
16:45-17:00 (OC8.7) De novo formation of purified infectious prions from minimal components
  
20:00 Gala Dinner

Friday 10 October 2008

Horario Auditorium
9:00-09:30 (S5) Plenary conference: Dr. Paul Brown
9:35-11:00 Poster Prizes Presentation
11:00-11:30 Coffee break
11:30-13:00 (11) Session 11. Hot topics
11:30-11:50 To be selected
11:50-12:10 To be selected
12:10-12:30 To be selected
12:30-12:50 To be selected
12:50-13:00 To be selected
13:00-13:30 Closing Ceremony